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Determination of conjugated compounds by liquid chromatography with electrochemical detection using post-column hydrolysis : Application to dopamine sulfate isomers  

作  者:Mary Ann Elchisak

机构地区:Department of Veterinary Physiology and Pharmacology, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907 U.S.A. ;

出  处:Journal of Chromatography A1983,255(000),475-482,8

语  种:外文

出 版 国:荷兰

摘  要:This report describes a post-column hydrolysis technique for the determination of dopamine-3-O-sulfate and dopamine-4-O-sulfate. The dopamine-sulfate isomers are separated by reversed-phase ion-pair liquid chromatography. Dopamine-3-O-sulfate and dopamine-4-O-sulfate are each hydrolyzed to free dopamine shortly after elution from the liquid chromatography column. Each isomer is then detected as free dopamine by electrochemical detection. Use of the technique results in a fifteen-fold increase in the signal-to-noise ratio for each of the dopamine-sulfate isomers when compared to a previous detection method utilizing ultraviolet detection.

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